| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SLC19A1 (452-591) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SLC19A1 |
| Gene ID: |
6573 |
| Uniprot ID: |
S19A1_HUMAN |
| Immunogen Region: |
452-591 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 452-591 of human SLC19A1 (NP_919231.1). |
| Immunogen Sequence: |
LDGLRHCQRGHHPRQPPAQG LRSAAEEKAAQALSVQDKGL GGLQPAQSPPLSPEDSLGAV GPASLEQRQSDPYLAQAPAP QAAEFLSPVTTPSPCTLCSA QASGPEAADETCPQLAVHPP GVSKLGLQCLPSDGVQNVNQ |
| Tissue Specificity | Placenta, liver, and to a much smaller extent, in lung. |
| Function | Antiporter that mediates the import of reduced folates or a subset of cyclic dinucleotides, driven by the export of organic anions. Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates. Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate. Also able to mediate the import of antifolate drug methotrexate. Also acts as an importer of immunoreactive cyclic dinucleotides, such as cyclic GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol, and its linkage isomer 3'-3'-cGAMP, thus playing a role in triggering larger immune responses. 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity. |
| Protein Name | Reduced Folate TransporterFoltCyclic Dinucleotide -Anion Antiporter Slc19a1Folate -Anion Antiporter Slc19a1Intestinal Folate Carrier 1Ifc-1Placental Folate TransporterReduced Folate Carrier ProteinRfcHrfcReduced Folate Transporter 1Rft-1Solute Carrier Family 19 Member 1Hslc19a1 |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneBasolateral Cell Membrane |
| Alternative Antibody Names | Anti-Reduced Folate Transporter antibodyAnti-Folt antibodyAnti-Cyclic Dinucleotide -Anion Antiporter Slc19a1 antibodyAnti-Folate -Anion Antiporter Slc19a1 antibodyAnti-Intestinal Folate Carrier 1 antibodyAnti-Ifc-1 antibodyAnti-Placental Folate Transporter antibodyAnti-Reduced Folate Carrier Protein antibodyAnti-Rfc antibodyAnti-Hrfc antibodyAnti-Reduced Folate Transporter 1 antibodyAnti-Rft-1 antibodyAnti-Solute Carrier Family 19 Member 1 antibodyAnti-Hslc19a1 antibodyAnti-SLC19A1 antibodyAnti-FLOT1 antibodyAnti-RFC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
