| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SKP1 (1-163) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SKP1 |
| Gene ID: |
6500 |
| Uniprot ID: |
SKP1_HUMAN |
| Immunogen Region: |
1-163 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-163 of human SKP1 (NP_733779.1). |
| Immunogen Sequence: |
MPSIKLQSSDGEIFEVDVEI AKQSVTIKTMLEDLGMDDEG DDDPVPLPNVNAAILKKVIQ WCTHHKDDPPPPEDDENKEK RTDDIPVWDQEFLKVDQGTL FELILAANYLDIKGLLDVTC KTVANMIKGKTPEEIRKTFN IKNDFTEEEEAQVRKENQWC EEK |
| Post Translational Modifications | Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. |
| Function | Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'.the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. |
| Protein Name | S-Phase Kinase-Associated Protein 1Cyclin-A/Cdk2-Associated Protein P19P19aOrgan Of Corti Protein 2Ocp-2Organ Of Corti Protein IiOcp-IiRna Polymerase Ii Elongation Factor-Like ProteinSiiiTranscription Elongation Factor B Polypeptide 1-LikeP19skp1 |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-1170546Reactome: R-HSA-174113Reactome: R-HSA-180534Reactome: R-HSA-187577Reactome: R-HSA-195253Reactome: R-HSA-202424Reactome: R-HSA-2122947Reactome: R-HSA-2565942Reactome: R-HSA-2644606Reactome: R-HSA-2644607Reactome: R-HSA-2871837Reactome: R-HSA-2894862Reactome: R-HSA-400253Reactome: R-HSA-5607761Reactome: R-HSA-5607764Reactome: R-HSA-5610780Reactome: R-HSA-5610783Reactome: R-HSA-5610785Reactome: R-HSA-5676590Reactome: R-HSA-5684264Reactome: R-HSA-68949Reactome: R-HSA-69231Reactome: R-HSA-8854050Reactome: R-HSA-8939902Reactome: R-HSA-8951664Reactome: R-HSA-9020702Reactome: R-HSA-917937Reactome: R-HSA-9604323Reactome: R-HSA-9708530Reactome: R-HSA-9725371Reactome: R-HSA-9762114Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-S-Phase Kinase-Associated Protein 1 antibodyAnti-Cyclin-A/Cdk2-Associated Protein P19 antibodyAnti-P19a antibodyAnti-Organ Of Corti Protein 2 antibodyAnti-Ocp-2 antibodyAnti-Organ Of Corti Protein Ii antibodyAnti-Ocp-Ii antibodyAnti-Rna Polymerase Ii Elongation Factor-Like Protein antibodyAnti-Siii antibodyAnti-Transcription Elongation Factor B Polypeptide 1-Like antibodyAnti-P19skp1 antibodyAnti-SKP1 antibodyAnti-EMC19 antibodyAnti-OCP2 antibodyAnti-SKP1A antibodyAnti-TCEB1L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
