Anti-SIGIRR antibody (1-120 aa) (STJ11105985)

SKU:
STJ11105985
€140.63 - €655.63
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Gene Symbol: SIGIRR
Gene ID: 59307
Uniprot ID: SIGIR_HUMAN
Immunogen Region: 1-120 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SIGIRR (NP_068577.2).
Immunogen Sequence: MPGVCDRAPDFLSPSEDQVL RPALGSSVALNCTAWVVSGP HCSLPSVQWLKDGLPLGIGG HYSLHEYSWVKANLSEVLVS SVLGVNVTSTEVYGAFTCSI QNISFSSFTLQRAGPTSHVA
Tissue Specificity Mainly expressed in epithelial tissues such as kidney, lung and gut.
Function Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP.
Protein Name Single Ig Il-1-Related Receptor
Single Ig Il-1r-Related Molecule
Single Immunoglobulin Domain-Containing Il1r-Related Protein
Toll/Interleukin-1 Receptor 8
Tir8
Database Links Reactome: R-HSA-166058
Reactome: R-HSA-9008059
Cellular Localisation Membrane
Single-Pass Type Iii Membrane Protein
Alternative Antibody Names Anti-Single Ig Il-1-Related Receptor antibody
Anti-Single Ig Il-1r-Related Molecule antibody
Anti-Single Immunoglobulin Domain-Containing Il1r-Related Protein antibody
Anti-Toll/Interleukin-1 Receptor 8 antibody
Anti-Tir8 antibody
Anti-SIGIRR antibody
Anti-UNQ301 antibody
Anti-PRO342 antibody

Information sourced from Uniprot.org

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