| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
SIGIRR |
| Gene ID: |
59307 |
| Uniprot ID: |
SIGIR_HUMAN |
| Immunogen Region: |
1-120 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SIGIRR (NP_068577.2). |
| Immunogen Sequence: |
MPGVCDRAPDFLSPSEDQVL RPALGSSVALNCTAWVVSGP HCSLPSVQWLKDGLPLGIGG HYSLHEYSWVKANLSEVLVS SVLGVNVTSTEVYGAFTCSI QNISFSSFTLQRAGPTSHVA |
| Tissue Specificity | Mainly expressed in epithelial tissues such as kidney, lung and gut. |
| Function | Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. |
| Protein Name | Single Ig Il-1-Related ReceptorSingle Ig Il-1r-Related MoleculeSingle Immunoglobulin Domain-Containing Il1r-Related ProteinToll/Interleukin-1 Receptor 8Tir8 |
| Database Links | Reactome: R-HSA-166058Reactome: R-HSA-9008059 |
| Cellular Localisation | MembraneSingle-Pass Type Iii Membrane Protein |
| Alternative Antibody Names | Anti-Single Ig Il-1-Related Receptor antibodyAnti-Single Ig Il-1r-Related Molecule antibodyAnti-Single Immunoglobulin Domain-Containing Il1r-Related Protein antibodyAnti-Toll/Interleukin-1 Receptor 8 antibodyAnti-Tir8 antibodyAnti-SIGIRR antibodyAnti-UNQ301 antibodyAnti-PRO342 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
