| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SH3KBP1 (136-271) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SH3KBP1 |
| Gene ID: |
30011 |
| Uniprot ID: |
SH3K1_HUMAN |
| Immunogen Region: |
136-271 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 136-271 of human SH3KBP1 (NP_114098.1). |
| Immunogen Sequence: |
WEGVLNGKTGMFPSNFIKEL SGESDELGISQDEQLSKSSL RETTGSESDGGDSSSTKSEG ANGTVATAAIQPKKVKGVGF GDIFKDKPIKLRPRSIEVEN DFLPVEKTIGKKLPATTATP DSSKTEMDSRTKSKDY |
| Tissue Specificity | Ubiquitously expressed. Also expressed in some cancer cell lines. |
| Post Translational Modifications | Monoubiquitinated by CBL and CBLB after EGF stimulation.probably on its C-terminus. |
| Function | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion.promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation. |
| Protein Name | Sh3 Domain-Containing Kinase-Binding Protein 1Cd2-Binding Protein 3Cd2bp3Cbl-Interacting Protein Of 85 KdaHuman Src Family Kinase-Binding Protein 1Hsb-1 |
| Database Links | Reactome: R-HSA-182971Reactome: R-HSA-6807004Reactome: R-HSA-8856825Reactome: R-HSA-8856828Reactome: R-HSA-8866376Reactome: R-HSA-8875360Reactome: R-HSA-9679191Reactome: R-HSA-983695 |
| Cellular Localisation | CytoplasmCytoskeletonCytoplasmic Vesicle MembranePeripheral Membrane ProteinSynapseSynaptosomeCell JunctionFocal AdhesionLocalized In Endocytic Vesicles Containing Clustered ReceptorsColocalizes With Asap1 In Vesicular StructuresColocalized With Actin Microfilaments And Focal AdhesionsColocalized With Magi2 In SynaptosomesTranslocation To Egfr Containing Vesicles Upon Egf Stimulation Is Inhibited In The Presence Of Sh3kbp1Colocalizes With Zfp36 In The Cytoplasm |
| Alternative Antibody Names | Anti-Sh3 Domain-Containing Kinase-Binding Protein 1 antibodyAnti-Cd2-Binding Protein 3 antibodyAnti-Cd2bp3 antibodyAnti-Cbl-Interacting Protein Of 85 Kda antibodyAnti-Human Src Family Kinase-Binding Protein 1 antibodyAnti-Hsb-1 antibodyAnti-SH3KBP1 antibodyAnti-CIN85 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
