| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SF3A2 |
| Gene ID: |
8175 |
| Uniprot ID: |
SF3A2_HUMAN |
| Immunogen Region: |
1-220 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SF3A2 (NP_009096.2). |
| Immunogen Sequence: |
MDFQHRPGGKTGSGGVASSS ESNRDRRERLRQLALETIDI NKDPYFMKNHLGSYECKLCL TLHNNEGSYLAHTQGKKHQT NLARRAAKEAKEAPAQPAPE KVKVEVKKFVKIGRPGYKVT KQRDSEMGQQSLLFQIDYPE IAEGIMPRHRFMSAYEQRIE PPDRRWQYLLMAAEPYETIA FKVPSREIDKAEGKFWTHWN RETKQFFLQFHFKMEKPPAP |
| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron. |
| Protein Name | Splicing Factor 3a Subunit 2Sf3a66Spliceosome-Associated Protein 62Sap 62 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor 3a Subunit 2 antibodyAnti-Sf3a66 antibodyAnti-Spliceosome-Associated Protein 62 antibodyAnti-Sap 62 antibodyAnti-SF3A2 antibodyAnti-SAP62 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
