| Function | Filament-forming cytoskeletal GTPase (Probable). Plays an important role in male fertility and sperm motility. During spermiogenesis, essential for the establishment of the annulus (a fibrous ring structure connecting the midpiece and the principal piece of the sperm flagellum) which is a requisite for the structural and mechanical integrity of the sperm. Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development. Isoform ARTS: Required for the induction of cell death mediated by TGF-beta and possibly by other apoptotic stimuli. Induces apoptosis through binding and inhibition of XIAP resulting in significant reduction in XIAP levels, leading to caspase activation and cell death. |
| Protein Name | Septin-4Apoptosis-Related Protein In The Tgf-Beta Signaling PathwayArtsBradeion BetaBrain Protein H5Ce5b3 BetaCell Division Control-Related Protein 2Hcdcrel-2Cerebral Protein 7Peanut-Like Protein 2 |
| Database Links | Reactome: R-HSA-111457 O43236-6Reactome: R-HSA-111469 O43236-6 |
| Cellular Localisation | CytoplasmCell ProjectionCiliumFlagellumCytoplasmic VesicleSecretory VesicleAxonDendritePerikaryonIn PlateletsFound In Areas Surrounding Alpha-GranulesFound In The Sperm AnnulusA Fibrous Ring Structure Connecting The Midpiece And The Principal Piece Of The Sperm FlagellumIsoform Arts: MitochondrionNucleusWhile Predominantly Localized In The Mitochondria Under Resting ConditionsTranslocates Into The Nucleus After Tgf-Beta Treatment And Apoptosis Induction |
| Alternative Antibody Names | Anti-Septin-4 antibodyAnti-Apoptosis-Related Protein In The Tgf-Beta Signaling Pathway antibodyAnti-Arts antibodyAnti-Bradeion Beta antibodyAnti-Brain Protein H5 antibodyAnti-Ce5b3 Beta antibodyAnti-Cell Division Control-Related Protein 2 antibodyAnti-Hcdcrel-2 antibodyAnti-Cerebral Protein 7 antibodyAnti-Peanut-Like Protein 2 antibodyAnti-SEPTIN4 antibodyAnti-ARTS antibodyAnti-C17orf47 antibodyAnti-PNUTL2 antibodyAnti-SEP4 antibodyAnti-SEPT4 antibodyAnti-hucep-7 antibody |
Information sourced from Uniprot.org
