| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SEPT12 (189-358) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SEPTIN12 |
| Gene ID: |
124404 |
| Uniprot ID: |
SEP12_HUMAN |
| Immunogen Region: |
189-358 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 189-358 of human Septin 12 (NP_653206.2). |
| Immunogen Sequence: |
VVPVIARADSLTMEEREAFR RRIQQNLRTHCIDVYPQMCF DEDINDKILNSKLRDRIPFA VVGADQEHLVNGRCVLGRKT KWGIIEVENMAHCEFPLLRD LLIRSHLQDLKDITHNIHYE NYRVIRLNESHLLPRGPGWV NLAPASPGQLTTPRTFKVCR GAHDDSDDEF |
| Tissue Specificity | Widely expressed. Expressed in lymph node. |
| Function | Filament-forming cytoskeletal GTPase. Involved in spermatogenesis. Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins. Forms a filamentous structure with SEPTIN7, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. May play a role in cytokinesis (Potential). |
| Protein Name | Septin-12 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleNucleusCell ProjectionCiliumFlagellumAt InterphaseForms A Filamentous Structure In The CytoplasmDuring AnaphaseTranslocates To The Central Spindle Region And To The Midbody During CytokinesisFound In The Sperm AnnulusColocalized With Spag4 At The Nuclear Periphery In Round SpermatidsAt Sperm Neck In Elongated Spermatids And At Midpiece Regions In Ejaculated Spermatozoa |
| Alternative Antibody Names | Anti-Septin-12 antibodyAnti-SEPTIN12 antibodyAnti-SEPT12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
