| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SEMA4D (753-862) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SEMA4D |
| Gene ID: |
10507 |
| Uniprot ID: |
SEM4D_HUMAN |
| Immunogen Region: |
753-862 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 753-862 of human SEMA4D (NP_006369.3). |
| Immunogen Sequence: |
YNCYKGYLPRQCLKFRSALL IGKKKPKSDFCDREQSLKET LVEPGSFSQQNGEHPKPALD TGYETEQDTITSKVPTDRED SQRIDDLSARDKPFDVKCEL KFADSDADGD |
| Tissue Specificity | Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. |
| Function | Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling. Regulates GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner. Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA. Promotes the migration of cerebellar granule cells. Plays a role in the immune system.induces B-cells to aggregate and improves their viability (in vitro). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway. |
| Protein Name | Semaphorin-4dA8Bb18Gr3Cd Antigen Cd100 |
| Database Links | Reactome: R-HSA-416550Reactome: R-HSA-416572Reactome: R-HSA-416700 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Semaphorin-4d antibodyAnti-A8 antibodyAnti-Bb18 antibodyAnti-Gr3 antibodyAnti-Cd Antigen Cd100 antibodyAnti-SEMA4D antibodyAnti-C9orf164 antibodyAnti-CD100 antibodyAnti-SEMAJ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
