| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SCO1 |
| Gene ID: | 6341 |
| Uniprot ID: | SCO1_HUMAN |
| Immunogen Region: | 1-160 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human SCO1 (NP_004580.1). |
| Immunogen Sequence: | MAMLVLVPGRVMRPLGGQLW RFLPRGLEFWGPAEGTARVL LRQFCARQAEAWRASGRPGY CLGTRPLSTARPPPPWSQKG PGDSTRPSKPGPVSWKSLAI TFAIGGALLAGMKHVKKEKA EKLEKERQRHIGKPLLGGPF SLTTHTGERKTDKDYLGQWL |
| Tissue Specificity | Predominantly expressed in tissues characterized by high rates of oxidative phosphorylation (OxPhos), including muscle, heart, and brain. |
| Function | Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Not required for the synthesis of MT-CO2/COX2 but plays a crucial role in stabilizing MT-CO2/COX2 during its subsequent maturation. Involved in transporting copper to the Cu(A) site on MT-CO2/COX2. Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1. |
| Protein Name | Protein Sco1 Homolog - Mitochondrial |
| Database Links | Reactome: R-HSA-9864848 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Sco1 Homolog - Mitochondrial antibodyAnti-SCO1 antibodyAnti-SCOD1 antibody |
Information sourced from Uniprot.org