| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCNN1A (390-440 aa) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
SCNN1A |
| Gene ID: |
6337 |
| Uniprot ID: |
SCNNA_HUMAN |
| Immunogen Region: |
390-440 aa |
| Specificity: |
Specific for SCNN1A. |
| Immunogen: |
A synthetic peptide from aa region 390-440 of the extracellular domain of human SCNN1A conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. N-glycosylated. |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception. |
| Protein Name | Amiloride-Sensitive Sodium Channel Subunit AlphaAlpha-NachEpithelial Na(+ Channel Subunit AlphaAlpha-EnacEnacaNonvoltage-Gated Sodium Channel 1 Subunit AlphaScnea |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCiliumCytoplasmic GranuleCytoplasmCytoplasmic VesicleSecretory VesicleAcrosomeFlagellumIn The Oviduct And BronchusLocated On Cilia In Multi-Ciliated CellsIn Endometrial Non-Ciliated Epithelial CellsRestricted To Apical SurfacesIn EpidermisLocated Nearly Uniformly In The Cytoplasm In A Granular DistributionIn Sebaceous GlandsObserved Only In The Cytoplasmic Space In Between The Lipid VesiclesIn Eccrine Sweat GlandsMainly Located At The Apical Surface Of The Cells Facing The LumenIn SkinIn Arrector Pili Muscle Cells And In AdipocytesLocated In The Cytoplasm And Colocalized With Actin FibersIn SpermatogoniaSpermatocytes And Round SpermatidsLocated In The CytoplasmPrior To SpermiationLocation Shifts From The Cytoplasm To The Spermatid TailIn SpermatozoaLocalizes At The Acrosome And The Central Region Of The Sperm Flagellum |
| Alternative Antibody Names | Anti-Amiloride-Sensitive Sodium Channel Subunit Alpha antibodyAnti-Alpha-Nach antibodyAnti-Epithelial Na(+ Channel Subunit Alpha antibodyAnti-Alpha-Enac antibodyAnti-Enaca antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Alpha antibodyAnti-Scnea antibodyAnti-SCNN1A antibodyAnti-SCNN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
