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Anti-SARS antibody (1-300) (STJ28816)

Immunofluorescence analysis of MCF7 cells using SARS antibody (STJ28816). Blue: DAPI for nuclear staining.
Immunohistochemistry analysis of paraffin-embedded rat ovary using SARS Rabbit polyclonal antibody (STJ28816) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
Western blot analysis of extracts of various cell lines, using SARS antibody (STJ28816) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-SARS antibody (1-300) (STJ28816)

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STJ28816

£169.50 - £449.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	WB/IHC/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-SARS (1-300) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IHC-P 1:50-1:200 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	SARS1
Gene ID:	6301
Uniprot ID:	SYSC_HUMAN
Immunogen Region:	1-300
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human SARS (NP_006504.2).
Immunogen Sequence:	MVLDLDLFRVDKGGDPALIR ETQEKRFKDPGLVDQLVKAD SEWRRCRFRADNLNKLKNLC SKTIGEKMKKKEPVGDDESV PENVLSFDDLTADALANLKV SQIKKVRLLIDEAILKCDAE RIKLEAERFENLREIGNLLH PSVPISNDEDVDNKVERIWG DCTVRKKYSHVDLVVMVDGF EGEKGAVVAGSRGYFLKGVL VFLEQALIQYALRTLGSRGY IPIYTPFFMRKEVMQEVAQ

Tissue Specificity	Brain.
Function	Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
Protein Name	Serine--Trna Ligase - Cytoplasmic Seryl-Trna Synthetase Serrs Seryl-Trna(Ser/Sec Synthetase
Database Links	Reactome: R-HSA-2408557 Reactome: R-HSA-379716
Cellular Localisation	Cytoplasm Nucleus Predominantly Cytoplasmic But A Minor Proportion Is Also Found In The Nucleus
Alternative Antibody Names	Anti-Serine--Trna Ligase - Cytoplasmic antibody Anti-Seryl-Trna Synthetase antibody Anti-Serrs antibody Anti-Seryl-Trna(Ser/Sec Synthetase antibody Anti-SARS1 antibody Anti-SARS antibody Anti-SERS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance

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