| Tissue Specificity | Detected in heart, brain, lung, liver, kidney, pancreas and testis. |
| Function | Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (PtdIns(4)P). Can also catalyze the hydrolysis of phosphatidylinositol 3-phosphate (PtdIns(3)P) and has low activity towards phosphatidylinositol-3,5-bisphosphate (PtdIns(3,5)P2). Shows a very robust PtdIns(4)P phosphatase activity when it binds PtdIns(4)P in a 'cis' configuration in the cellular environment, with much less activity seen when it binds PtdIns(4)P in 'trans' configuration. PtdIns(4)P phosphatase activity (when it binds PtdIns(4)P in 'trans' configuration) is enhanced in the presence of PLEKHA3. |
| Protein Name | Phosphatidylinositol-3-Phosphatase Sac1Phosphatidylinositol-4-Phosphate PhosphataseSuppressor Of Actin Mutations 1-Like Protein |
| Database Links | Reactome: R-HSA-1483248Reactome: R-HSA-1660514 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneTrafficking Between The Er And Golgi Is Regulated By Nutrient Status And By Tmem39aLocalizes To Endoplasmic Reticulum-Plasma Membrane Contact Sites (Epcs) In The Presence Of Phosphatidylinositol-45-Bisphosphate |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3-Phosphatase Sac1 antibodyAnti-Phosphatidylinositol-4-Phosphate Phosphatase antibodyAnti-Suppressor Of Actin Mutations 1-Like Protein antibodyAnti-SACM1L antibodyAnti-KIAA0851 antibodyAnti-SAC1 antibody |
Information sourced from Uniprot.org
