| Tissue Specificity | Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta and fetal spleen. Low-level signal detected in many tissue extracts. Overexpressed in leukemic large granular lymphocytes. Isoform 1 is predominantly expressed in peripheral tissues. Isoform 2 is expressed in brain, spleen and peripheral blood leukocytes. |
| Function | Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins. May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells. |
| Protein Name | Sphingosine 1-Phosphate Receptor 5S1p Receptor 5S1p5Endothelial Differentiation G-Protein-Coupled Receptor 8Sphingosine 1-Phosphate Receptor Edg-8S1p Receptor Edg-8 |
| Database Links | Reactome: R-HSA-418594Reactome: R-HSA-419408 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Sphingosine 1-Phosphate Receptor 5 antibodyAnti-S1p Receptor 5 antibodyAnti-S1p5 antibodyAnti-Endothelial Differentiation G-Protein-Coupled Receptor 8 antibodyAnti-Sphingosine 1-Phosphate Receptor Edg-8 antibodyAnti-S1p Receptor Edg-8 antibodyAnti-S1PR5 antibodyAnti-EDG8 antibody |
Information sourced from Uniprot.org
