• Immunohistochemistry analysis of paraffin-embedded rat heart using S100/S100A1 Rabbit monoclonal antibody (STJ11104162) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded mouse heart using S100/S100A1 Rabbit monoclonal antibody (STJ11104162) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human small intestine using S100/S100A1 Rabbit monoclonal antibody (STJ11104162) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human esophagus using S100/S100A1 Rabbit monoclonal antibody (STJ11104162) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using S100/S100A1 Rabbit monoclonal antibody (STJ11104162) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-S100A1 antibody [S4162RM] (STJ11104162)

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STJ11104162

£146.50 - £639.50
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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Protein S100-A1 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S4162RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: S100A1
Gene ID: 6271
Uniprot ID: S10A1_HUMAN
Tissue Specificity Highly prevalent in heart. Also found in lesser quantities in skeletal muscle and brain.
Post Translational Modifications Glutathionylated.glutathionylation increases affinity to calcium about 10-fold.
Function Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation. In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase. Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole.
Protein Name Protein S100-A1
S-100 Protein Alpha Chain
S-100 Protein Subunit Alpha
S100 Calcium-Binding Protein A1
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5686938
Cellular Localisation Cytoplasm
Sarcoplasmic Reticulum
Mitochondrion
Alternative Antibody Names Anti-Protein S100-A1 antibody
Anti-S-100 Protein Alpha Chain antibody
Anti-S-100 Protein Subunit Alpha antibody
Anti-S100 Calcium-Binding Protein A1 antibody
Anti-S100A1 antibody
Anti-S100A antibody

Information sourced from Uniprot.org

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