| Tissue Specificity | Predominantly expressed in brain. Expressed at lower levels in kidney, lung, mammary gland, placenta, salivary gland, skeletal muscle and spleen. |
| Function | Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis.protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development. Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton. |
| Protein Name | Reticulon-4 Receptor-Like 1Nogo Receptor-Like 2Nogo-66 Receptor Homolog 2Nogo-66 Receptor-Related Protein 3Ngr3 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane RaftPerikaryonCell ProjectionLocalized To The Surface Of NeuronsIncluding Axons |
| Alternative Antibody Names | Anti-Reticulon-4 Receptor-Like 1 antibodyAnti-Nogo Receptor-Like 2 antibodyAnti-Nogo-66 Receptor Homolog 2 antibodyAnti-Nogo-66 Receptor-Related Protein 3 antibodyAnti-Ngr3 antibodyAnti-RTN4RL1 antibodyAnti-NGRH2 antibodyAnti-NGRL2 antibody |
Information sourced from Uniprot.org
