| Function | Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagC/RRAGC is in its active form when GDP-bound RagC/RRAGC forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagC/RRAGC heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB). In its GDP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the MTOR signaling cascade by amino acids. Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagC/RRAGC mediates recruitment of MiT/TFE factors TFEB and TFE3. |
| Protein Name | Ras-Related Gtp-Binding Protein CRag CRagcGtpase-Interacting Protein 2Tib929 |
| Database Links | Reactome: R-HSA-1632852Reactome: R-HSA-165159Reactome: R-HSA-166208Reactome: R-HSA-380972Reactome: R-HSA-5628897Reactome: R-HSA-8943724Reactome: R-HSA-9639288 |
| Cellular Localisation | CytoplasmNucleusLysosome MembranePredominantly CytoplasmicRecruited To The Lysosome Surface By The Ragulator ComplexMay Shuttle Between The Cytoplasm And NucleusDepending On The Bound Nucleotide State Of Associated Rraga |
| Alternative Antibody Names | Anti-Ras-Related Gtp-Binding Protein C antibodyAnti-Rag C antibodyAnti-Ragc antibodyAnti-Gtpase-Interacting Protein 2 antibodyAnti-Tib929 antibodyAnti-RRAGC antibody |
Information sourced from Uniprot.org
