| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNF144B |
| Gene ID: |
255488 |
| Uniprot ID: |
R144B_HUMAN |
| Immunogen Region: |
1-200 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human RNF144B (NP_877434.2). |
| Immunogen Sequence: |
MGSAGRLHYLAMTAENPTPG DLAPAPLITCKLCLCEQSLD KMTTLQECQCIFCTACLKQY MQLAIREGCGSPITCPDMVC LNHGTLQEAEIACLVPVDQF QLYQRLKFEREVHLDPYRTW CPVADCQTVCPVASSDPGQP VLVECPSCHLKFCSCCKDAW HAEVSCRDSQPIVLPTEHRA LFGTDAEAPIKQCPVCRVYI |
| Tissue Specificity | Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis. |
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. However, its overexpression also produces a decrease of the ubiquitin-dependent stability of BAX, a pro-apoptotic protein, ultimately leading to protection of cell death.But, it is not an anti-apoptotic protein per se. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf144bIbr Domain-Containing Protein 2Ring Finger Protein 144bP53-Inducible Ring Finger Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Mitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmMostly CytosololicAccumulates In Submitochondrial Domains Specifically Upon Apoptosis InductionIn Synchrony With Bax Activation |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Rnf144b antibodyAnti-Ibr Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 144b antibodyAnti-P53-Inducible Ring Finger Protein antibodyAnti-RNF144B antibodyAnti-IBRDC2 antibodyAnti-P53RFP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
