| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ribonuclease T2 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RNASET2 |
| Gene ID: |
8635 |
| Uniprot ID: |
RNT2_HUMAN |
| Specificity: |
This antibody detects endogenous levels of RNase T2 at Human, Mouse |
| Immunogen: |
Synthesized peptide derived from human RNase T2 |
| Function | Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. |
| Protein Name | Ribonuclease T2Ribonuclease 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedLysosome LumenEndoplasmic Reticulum LumenMitochondrion Intermembrane SpaceFull-Length Rnaset2 Is Found In The Endoplasmic Reticulum While Smaller Rnaset2 Proteolytic Products Are Found In The Lysosome Fraction |
| Alternative Antibody Names | Anti-Ribonuclease T2 antibodyAnti-Ribonuclease 6 antibodyAnti-RNASET2 antibodyAnti-RNASE6PL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
