| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RLBP1 |
| Gene ID: | 6017 |
| Uniprot ID: | RLBP1_HUMAN |
| Immunogen Region: | 1-317 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human CRALBP (NP_000317.1). |
| Immunogen Sequence: | MSEGVGTFRMVPEEEQELRA QLEQLTTKDHGPVFGPCSQL PRHTLQKAKDELNEREETRE EAVRELQEMVQAQAASGEEL AVAVAERVQEKDSGFFLRFI RARKFNVGRAYELLRGYVNF RLQYPELFDSLSPEAVRCTI EAGYPGVLSSRDKYGRVVML FNIENWQSQEITFDEILQAY CFILEKLLENEETQINGFCI IENFKGFTMQQAASLRTSDL RKMVDMLQDSFPARFKAIH |
| Tissue Specificity | Retina and pineal gland. Not present in photoreceptor cells but is expressed abundantly in the adjacent retinal pigment epithelium (RPE) and in the Mueller glial cells of the retina. |
| Function | Soluble retinoid carrier essential the proper function of both rod and cone photoreceptors. Participates in the regeneration of active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-trans products of the rhodopsin photocycle and in the de novo synthesis of these retinoids from 11-trans metabolic precursors. The cycling of retinoids between photoreceptor and adjacent pigment epithelium cells is known as the 'visual cycle'. |
| Protein Name | Retinaldehyde-Binding Protein 1Cellular Retinaldehyde-Binding Protein |
| Database Links | Reactome: R-HSA-2187335Reactome: R-HSA-2453864Reactome: R-HSA-2453902 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Retinaldehyde-Binding Protein 1 antibodyAnti-Cellular Retinaldehyde-Binding Protein antibodyAnti-RLBP1 antibodyAnti-CRALBP antibody |
Information sourced from Uniprot.org