| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RGS3 |
| Gene ID: | 5998 |
| Uniprot ID: | RGS3_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human RGS3 (NP_570613.2). |
| Immunogen Sequence: | MNRFNGLCKVCSERRYRQIT IPRGKDGFGFTICCDSPVRV QAVDSGGPAERAGLQQLDTV LQLNERPVEHWKCVELAHEI RSCPSEIILLVWRMVPQVKP GPDGGVLRRASCKSTHDLQS PPNKREKNCTHGVQARPEQR HSCHLVCDSSDGLLLGGWER YTEVAKRGGQHTLPALSRAT APTDPNYIILAPLNPGSQLL RPVYQEDTIPEESGSPSKGK SYTGLGKKSRLMKTVQTMK |
| Post Translational Modifications | Phosphorylated by cyclic GMP-dependent protein kinase. ISGylated. |
| Function | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. |
| Protein Name | Regulator Of G-Protein Signaling 3Rgp3Rgs3 |
| Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinLong Isoforms Are Cytoplasmic And Associated With The Plasma MembraneShort Isoforms Are Nuclear |
| Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 3 antibodyAnti-Rgp3 antibodyAnti-Rgs3 antibodyAnti-RGS3 antibody |
Information sourced from Uniprot.org