Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | RGS3 |
Gene ID: | 5998 |
Uniprot ID: | RGS3_HUMAN |
Immunogen Region: | 1-270 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human RGS3 (NP_570613.2). |
Immunogen Sequence: | MNRFNGLCKVCSERRYRQIT IPRGKDGFGFTICCDSPVRV QAVDSGGPAERAGLQQLDTV LQLNERPVEHWKCVELAHEI RSCPSEIILLVWRMVPQVKP GPDGGVLRRASCKSTHDLQS PPNKREKNCTHGVQARPEQR HSCHLVCDSSDGLLLGGWER YTEVAKRGGQHTLPALSRAT APTDPNYIILAPLNPGSQLL RPVYQEDTIPEESGSPSKGK SYTGLGKKSRLMKTVQTMK |
Post Translational Modifications | Phosphorylated by cyclic GMP-dependent protein kinase. ISGylated. |
Function | Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases. |
Protein Name | Regulator Of G-Protein Signaling 3Rgp3Rgs3 |
Database Links | Reactome: R-HSA-416476Reactome: R-HSA-418594 |
Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinLong Isoforms Are Cytoplasmic And Associated With The Plasma MembraneShort Isoforms Are Nuclear |
Alternative Antibody Names | Anti-Regulator Of G-Protein Signaling 3 antibodyAnti-Rgp3 antibodyAnti-Rgs3 antibodyAnti-RGS3 antibody |
Information sourced from Uniprot.org