| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RGMB |
| Gene ID: | 285704 |
| Uniprot ID: | RGMB_HUMAN |
| Immunogen Region: | 210-453 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 210-453 of human RGMB (NP_001012779.2). |
| Immunogen Sequence: | PHLRTFKDNFQTCKVEGAWP LIDNNYLSVQVTNVPVVPGS SATATNKITIIFKAHHECTD QKVYQAVTDDLPAAFVDGTT SGGDSDAKSLRIVERESGHY VEMHARYIGTTVFVRQVGRY LTLAIRMPEDLAMSYEESQD LQLCVNGCPLSERIDDGQGQ VSAILGHSLPRTSLVQAWPG YTLETANTQCHEKMPVKDIY FQSCVFDLLTTGDANFTAAA HSALEDVEALHPRKERWHI |
| Post Translational Modifications | GPI-anchored. Autocatalytically cleaved at low pH.the two chains remain linked via two disulfide bonds. |
| Function | Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system. Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling. Promotes neuronal adhesion. May inhibit neurite outgrowth. |
| Protein Name | Repulsive Guidance Molecule BDrg11-Responsive Axonal Guidance And Outgrowth Of NeuriteDragon |
| Database Links | Reactome: R-HSA-373752 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorMembrane Raft |
| Alternative Antibody Names | Anti-Repulsive Guidance Molecule B antibodyAnti-Drg11-Responsive Axonal Guidance And Outgrowth Of Neurite antibodyAnti-Dragon antibodyAnti-RGMB antibody |
Information sourced from Uniprot.org