| Host: |
Rabbit |
| Applications: |
IHC/IP/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal antibody anti-Recombinant-Nuclear Receptor Coactivator 1 is suitable for use in Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
RM2G63 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Dilution Range: |
IHC: 1:50-1:100, IP: 1:20, WB: 1:500-1:1000 |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Post Translational Modifications | Sumoylated.sumoylation increases its interaction with PGR and prolongs its retention in the nucleus. It does not prevent its ubiquitination and does not exert a clear effect on the stability of the protein. Ubiquitinated.leading to proteasome-mediated degradation. Ubiquitination and sumoylation take place at different sites. |
| Function | Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4.the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3. |
| Protein Name | Nuclear Receptor Coactivator 1Ncoa-1Class E Basic Helix-Loop-Helix Protein 74Bhlhe74Protein Hin-2Rip160Renal Carcinoma Antigen Ny-Ren-52Steroid Receptor Coactivator 1Src-1 |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-159418Reactome: R-HSA-192105Reactome: R-HSA-193368Reactome: R-HSA-193807Reactome: R-HSA-1989781Reactome: R-HSA-211976Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-3214847Reactome: R-HSA-381340Reactome: R-HSA-3899300Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9029569Reactome: R-HSA-9623433Reactome: R-HSA-9707564Reactome: R-HSA-9707616Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Coactivator 1 antibodyAnti-Ncoa-1 antibodyAnti-Class E Basic Helix-Loop-Helix Protein 74 antibodyAnti-Bhlhe74 antibodyAnti-Protein Hin-2 antibodyAnti-Rip160 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-52 antibodyAnti-Steroid Receptor Coactivator 1 antibodyAnti-Src-1 antibodyAnti-NCOA1 antibodyAnti-BHLHE74 antibodyAnti-SRC1 antibody |
Information sourced from Uniprot.org
