| Post Translational Modifications | Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1. Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome. Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. |
| Function | Ionotropic glutamate receptor that functions as a cation permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. Modulates cell surface expression of NETO2. In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses. Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures. Functions in dorsal root ganglion neurons. |
| Protein Name | Glutamate Receptor Ionotropic - Kainate 2Gluk2Excitatory Amino Acid Receptor 4Eaa4Glutamate Receptor 6Glur-6Glur6 |
| Database Links | Reactome: R-HSA-451307Reactome: R-HSA-451308 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Glutamate Receptor Ionotropic - Kainate 2 antibodyAnti-Gluk2 antibodyAnti-Excitatory Amino Acid Receptor 4 antibodyAnti-Eaa4 antibodyAnti-Glutamate Receptor 6 antibodyAnti-Glur-6 antibodyAnti-Glur6 antibodyAnti-GRIK2 antibodyAnti-GLUR6 antibody |
Information sourced from Uniprot.org
