Anti-Recombinant-CLPTM1 antibody [RM1G91] (STJA0023283)

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STJA0023283
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Covered by St John's Laboratory Guarantee

Host: Rabbit
Applications: FC/IF/IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Putative Lipid Scramblase Clptm1 is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1G91
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: CLPTM1
Gene ID: 1209
Uniprot ID: CLPT1_HUMAN
Function Involved in GABAergic but not glutamatergic transmission. Binds and traps GABAA receptors in the endoplasmic reticulum (ER). Modulates postsynaptic GABAergic transmission, and therefore inhibitory neurotransmission, by reducing the plasma membrane expression of these receptors. Altered GABAergic signaling is one among many causes of cleft palate. Might function as a lipid scramblase, translocating lipids in membranes from one leaflet to the other one. Required for efficient glycosylphosphatidylinositol (GPI) inositol deacylation in the ER, which is a crucial step to switch GPI-anchored proteins (GPI-APs) from protein folding to transport states. May play a role in T-cell development.
Protein Name Putative Lipid Scramblase Clptm1
Cleft Lip And Palate Transmembrane Protein 1
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Putative Lipid Scramblase Clptm1 antibody
Anti-Cleft Lip And Palate Transmembrane Protein 1 antibody
Anti-CLPTM1 antibody

Information sourced from Uniprot.org

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