| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RBM46 (1-140) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RBM46 |
| Gene ID: |
166863 |
| Uniprot ID: |
RBM46_HUMAN |
| Immunogen Region: |
1-140 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human RBM46 (NP_659416.1). |
| Immunogen Sequence: |
MNEENIDGTNGCSKVRTGIQ NEAALLALMEKTGYNMVQEN GQRKFGGPPPGWEGPPPPRG CEVFVGKIPRDMYEDELVPV FERAGKIYEFRLMMEFSGEN RGYAFVMYTTKEEAQLAIRI LNNYEIRPGKFIGVCVSLDN |
| Function | Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I. Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry. Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation. Required for spermatogonial differentiation in both developing and adult testis. |
| Protein Name | Probable Rna-Binding Protein 46Cancer/Testis Antigen 68Ct68Rna-Binding Motif Protein 46 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Probable Rna-Binding Protein 46 antibodyAnti-Cancer/Testis Antigen 68 antibodyAnti-Ct68 antibodyAnti-Rna-Binding Motif Protein 46 antibodyAnti-RBM46 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
