| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBM46 |
| Gene ID: | 166863 |
| Uniprot ID: | RBM46_HUMAN |
| Immunogen Region: | 1-140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human RBM46 (NP_659416.1). |
| Immunogen Sequence: | MNEENIDGTNGCSKVRTGIQ NEAALLALMEKTGYNMVQEN GQRKFGGPPPGWEGPPPPRG CEVFVGKIPRDMYEDELVPV FERAGKIYEFRLMMEFSGEN RGYAFVMYTTKEEAQLAIRI LNNYEIRPGKFIGVCVSLDN |
| Function | Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I. Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry. Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation. Required for spermatogonial differentiation in both developing and adult testis. |
| Protein Name | Probable Rna-Binding Protein 46Cancer/Testis Antigen 68Ct68Rna-Binding Motif Protein 46 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Probable Rna-Binding Protein 46 antibodyAnti-Cancer/Testis Antigen 68 antibodyAnti-Ct68 antibodyAnti-Rna-Binding Motif Protein 46 antibodyAnti-RBM46 antibody |
Information sourced from Uniprot.org