| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTPRK (600-750) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPRK |
| Gene ID: |
5796 |
| Uniprot ID: |
PTPRK_HUMAN |
| Immunogen Region: |
600-750 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 600-750 of human PTPRK (NP_001129120.1). |
| Immunogen Sequence: |
EGVDASLNETATTITVLLRP AQAKGAPISAYQIVVEELHP HRTKREAGAMECYQVPVTYQ NAMSGGAPYYFAAELPPGNL PEPAPFTVGDNRTYQGFWNP PLAPRKGYNIYFQAMSSVEK ETKTQCVRIATKAAATEEPE VIPDPAKQTDR |
| Tissue Specificity | High levels in lung, brain and colon.less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma. |
| Post Translational Modifications | This protein undergoes proteolytic processing. |
| Function | Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase KappaProtein-Tyrosine Phosphatase KappaR-Ptp-Kappa |
| Database Links | Reactome: R-HSA-182971 |
| Cellular Localisation | Cell JunctionAdherens JunctionCell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Kappa antibodyAnti-Protein-Tyrosine Phosphatase Kappa antibodyAnti-R-Ptp-Kappa antibodyAnti-PTPRK antibodyAnti-PTPK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
