Anti-PTPN22 antibody (1-90) (STJ25226)

SKU:
STJ25226
£112.50 - £524.50
Free Shipping
Processing The item has been added

Host: Rabbit
Applications: WB/IF/ICC/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTPN22
Gene ID: 26191
Uniprot ID: PTN22_HUMAN
Immunogen Region: 1-90
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human PTPN22 (NP_036543.4).
Immunogen Sequence: MDQREILQKFLDEAQSKKIT KEEFANEFLKLKRQSTKYKA DKTYPTTVAEKPKNIKKNRY KDILPYDYSRVELSLITSDE DSSYINANFI
Tissue Specificity Expressed in bone marrow, B and T-cells, PBMCs, natural killer cells, monocytes, dendritic cells and neutrophils. Both isoform 1 and 4 are predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells.
Post Translational Modifications Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases.
Function Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2. Positively regulates toll-like receptor (TLR)-induced type 1 interferon production. Promotes host antiviral responses mediated by type 1 interferon. Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy. Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3. Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide).
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type 22
Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-Pep
Lymphoid Phosphatase
Lyp
Pest-Domain Phosphatase
Pep
Database Links Reactome: R-HSA-202427
Reactome: R-HSA-202430
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 22 antibody
Anti-Hematopoietic Cell Protein-Tyrosine Phosphatase 70z-Pep antibody
Anti-Lymphoid Phosphatase antibody
Anti-Lyp antibody
Anti-Pest-Domain Phosphatase antibody
Anti-Pep antibody
Anti-PTPN22 antibody
Anti-PTPN8 antibody

Information sourced from Uniprot.org