• Western blot analysis of extracts of HepG2 cells, using PTPN12 antibody (STJ11103391) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 90s.

Anti-PTPN12 antibody (372-468) (STJ11103391)

SKU:
STJ11103391

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PTPN12 (372-468) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTPN12
Gene ID: 5782
Uniprot ID: PTN12_HUMAN
Immunogen Region: 372-468
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 372-468 of human PTPN12 (NP_002826.3).
Immunogen Sequence: SAFPTVTTVWQDNDRYHPKP VLHMVSSEQHSADLNRNYSK STELPGKNESTIEQIDKKLE RNLSFEIKKVPLQEGPKSFD GNTLLNRGHAIKIKSAS
Post Translational Modifications Phosphorylated by STK24/MST3 and this results in inhibition of its activity.
Function Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
Protein Name Tyrosine-Protein Phosphatase Non-Receptor Type 12
Ptp-Pest
Protein-Tyrosine Phosphatase G1
Ptpg1
Database Links Reactome: R-HSA-1250196
Reactome: R-HSA-182971
Reactome: R-HSA-186797
Reactome: R-HSA-8863795
Reactome: R-HSA-9008059
Reactome: R-HSA-9634285
Cellular Localisation Cytoplasm
Cell Junction
Focal Adhesion
Cell Projection
Podosome
Partial Translocation To Focal Adhesion Sites May Be Mediated By Interaction With Sorbs2
Alternative Antibody Names Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 12 antibody
Anti-Ptp-Pest antibody
Anti-Protein-Tyrosine Phosphatase G1 antibody
Anti-Ptpg1 antibody
Anti-PTPN12 antibody

Information sourced from Uniprot.org

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