| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTPMT1 (1-201) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTPMT1 |
| Gene ID: |
114971 |
| Uniprot ID: |
PTPM1_HUMAN |
| Immunogen Region: |
1-201 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human PTPMT1 (NP_783859.1). |
| Immunogen Sequence: |
MAATALLEAGLARVLFYPTL LYTLFRGKVPGRAHRDWYHR IDPTVLLGALPLRSLTRQLV QDENVRGVITMNEEYETRFL CNSSQEWKRLGVEQLRLSTV DMTGIPTLDNLQKGVQFALK YQSLGQCVYVHCKAGRSRSA TMVAAYLIQVHKWSPEEAVR AIAKIRSYIHIRPGQLDVLK EFHKQITARATKDGTFVISK T |
| Function | Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle. Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production. Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues. Probably involved in regulation of insulin secretion in pancreatic beta cells. May prevent intrinsic apoptosis, probably by regulating mitochondrial membrane integrity. |
| Protein Name | Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 1Pten-Like PhosphatasePhosphoinositide Lipid PhosphataseProtein-Tyrosine Phosphatase Mitochondrial 1 |
| Database Links | Reactome: R-HSA-1483148 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Phosphatidylglycerophosphatase And Protein-Tyrosine Phosphatase 1 antibodyAnti-Pten-Like Phosphatase antibodyAnti-Phosphoinositide Lipid Phosphatase antibodyAnti-Protein-Tyrosine Phosphatase Mitochondrial 1 antibodyAnti-PTPMT1 antibodyAnti-MOSP antibodyAnti-PLIP antibodyAnti-PNAS-129 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
