| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTGDR (220-359) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTGDR |
| Gene ID: |
5729 |
| Uniprot ID: |
PD2R_HUMAN |
| Immunogen Region: |
220-359 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-359 of human PTGDR (NP_000944.1). |
| Immunogen Sequence: |
GAMRNLYAMHRRLQRHPRSC TRDCAEPRADGREASPQPLE ELDHLLLLALMTVLFTMCSL PVIYRAYYGAFKDVKEKNRT SEEAEDLRALRFLSVISIVD PWIFIIFRSPVFRIFFHKIF IRPLRYRSRCSNSTNMESSL |
| Tissue Specificity | Expressed in retinal choroid, ciliary epithelium, longitudinal and circular ciliary muscles, iris, small intestine and platelet membranes. |
| Function | Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate. Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR. |
| Protein Name | Prostaglandin D2 ReceptorPgd ReceptorPgd2 ReceptorProstanoid Dp Receptor |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostaglandin D2 Receptor antibodyAnti-Pgd Receptor antibodyAnti-Pgd2 Receptor antibodyAnti-Prostanoid Dp Receptor antibodyAnti-PTGDR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
