| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human/Mouse/Cow |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-PRRX1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 28kDa band observed in Mouse Heart lysates, and approx. 22-23kDa in lysates of cell line LNCaP (calculated MW of 24.4kDa according to Human NP_008833.1) and 27.3kDa according to |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
PRRX1 |
| Gene ID: |
5396 |
| Uniprot ID: |
PRRX1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_008833.1; NP_073207.1 |
| Specificity: |
This antibody is expected to recognise both reported isoforms (NP_008833.1; NP_073207.1). |
| Immunogen Sequence: |
GSDTPQQDNDQ |
| Function | Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm. Isoform 1: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. Isoform 2: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. |
| Protein Name | Paired Mesoderm Homeobox Protein 1Homeobox Protein Phox1Paired-Related Homeobox Protein 1Prx-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Paired Mesoderm Homeobox Protein 1 antibodyAnti-Homeobox Protein Phox1 antibodyAnti-Paired-Related Homeobox Protein 1 antibodyAnti-Prx-1 antibodyAnti-PRRX1 antibodyAnti-PMX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
