| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PRKAR2B (1-100) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRKAR2B |
| Gene ID: | 5577 |
| Uniprot ID: | KAP3_HUMAN |
| Immunogen Region: | 1-100 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human PRKAR2B (NP_002727.2). |
| Immunogen Sequence: | MSIEIPAGLTELLQGFTVEV LRHQPADLLEFALQHFTRLQ QENERKGTARFGHEGRTWGD LGAAAGGGTPSKGVNFAEEP MQSDSEDGEEEEAAPADAGA |
| Tissue Specificity | Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible. |
| Post Translational Modifications | Phosphorylated by the activated catalytic chain. |
| Function | Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase. |
| Protein Name | Camp-Dependent Protein Kinase Type Ii-Beta Regulatory Subunit |
| Database Links | Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-180024Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-381676Reactome: R-HSA-432040Reactome: R-HSA-442720Reactome: R-HSA-5610787Reactome: R-HSA-5620912Reactome: R-HSA-8854518Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCell MembraneColocalizes With Pja2 In The Cytoplasm And At The Cell Membrane |
| Alternative Antibody Names | Anti-Camp-Dependent Protein Kinase Type Ii-Beta Regulatory Subunit antibodyAnti-PRKAR2B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
