| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRDX1 |
| Gene ID: | 5052 |
| Uniprot ID: | PRDX1_HUMAN |
| Immunogen Region: | 1-199 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human Peroxiredoxin 1/PAG (NP_001189360.1). |
| Immunogen Sequence: | MSSGNAKIGHPAPNFKATAV MPDGQFKDISLSDYKGKYVV FFFYPLDFTFVCPTEIIAFS DRAEEFKKLNCQVIGASVDS HFCHLAWVNTPKKQGGLGPM NIPLVSDPKRTIAQDYGVLK ADEGISFRGLFIIDDKGILR QITVNDLPVGRSVDETLRLV QAFQFTDKHGEVCPAGWKPG SDTIKPDVQKSKEYFSKQK |
| Post Translational Modifications | Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. |
| Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. |
| Protein Name | Peroxiredoxin-1 Natural Killer Cell-Enhancing Factor A Nkef-A Proliferation-Associated Gene Protein Pag Thioredoxin Peroxidase 2 Thioredoxin-Dependent Peroxide Reductase 2 Thioredoxin-Dependent Peroxiredoxin 1 |
| Database Links | Reactome: R-HSA-3299685 Reactome: R-HSA-5628897 Reactome: R-HSA-8862803 Reactome: R-HSA-9818027 |
| Cellular Localisation | Cytoplasm Melanosome Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Peroxiredoxin-1 antibody Anti-Natural Killer Cell-Enhancing Factor A antibody Anti-Nkef-A antibody Anti-Proliferation-Associated Gene Protein antibody Anti-Pag antibody Anti-Thioredoxin Peroxidase 2 antibody Anti-Thioredoxin-Dependent Peroxide Reductase 2 antibody Anti-Thioredoxin-Dependent Peroxiredoxin 1 antibody Anti-PRDX1 antibody Anti-PAGA antibody Anti-PAGB antibody Anti-TDPX2 antibody |
Information sourced from Uniprot.org