Anti-PPP4C antibody (1-307) (STJ25096)

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STJ25096
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Host: Rabbit
Applications: WB/IHC-P/IP/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cells
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PPP4C
Gene ID: 5531
Uniprot ID: PP4C_HUMAN
Immunogen Region: 1-307
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-307 of human PPP4C (NP_002711.1).
Immunogen Sequence: MAEISDLDRQIEQLRRCELI KESEVKALCAKAREILVEES NVQRVDSPVTVCGDIHGQFY DLKELFRVGGDVPETNYLFM GDFVDRGFYSVETFLLLLAL KVRYPDRITLIRGNHESRQI TQVYGFYDECLRKYGSVTVW RYCTEIFDYLSLSAIIDGKI FCVHGGLSPSIQTLDQIRTI DRKQEVPHDGPMCDLLWSDP EDTTGWGVSPRGAGYLFGSD VVAQFNAANDIDMICRAHQ
Post Translational Modifications Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair.
Function Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Protein Name Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit
Pp4c
Pp4
Protein Phosphatase X
Pp-X
Database Links Reactome: R-HSA-5693607
Cellular Localisation Cytoplasm
Nucleus
Cytoskeleton
Microtubule Organizing Center
Centrosome
Alternative Antibody Names Anti-Serine/Threonine-Protein Phosphatase 4 Catalytic Subunit antibody
Anti-Pp4c antibody
Anti-Pp4 antibody
Anti-Protein Phosphatase X antibody
Anti-Pp-X antibody
Anti-PPP4C antibody
Anti-PPP4 antibody
Anti-PPX antibody

Information sourced from Uniprot.org