• Western blot analysis of various lysates, using PGC1 beta Rabbit polyclonal antibody (STJ119414) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5min.

Anti-PPARGC1B antibody (850-950) (STJ119414)

SKU:
STJ119414

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PPARGC1B (850-950) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PPARGC1B
Gene ID: 133522
Uniprot ID: PRGC2_HUMAN
Immunogen Region: 850-950
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 850-950 of human PGC1 beta (NP_001166170.1).
Immunogen Sequence: SSRELKRRFEVFGEIEECEV LTRNRRGEKYGFITYRCSEH AALSLTKGAALRKRNEPSFQ LSYGGLRHFCWPRYTDYDSN SEEALPASGKSKYEAMDFDS L
Tissue Specificity Ubiquitous with higher expression in heart, brain and skeletal muscle.
Function Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Protein Name Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta
Pgc-1-Beta
Ppar-Gamma Coactivator 1-Beta
Ppargc-1-Beta
Pgc-1-Related Estrogen Receptor Alpha Coactivator
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2151201
Reactome: R-HSA-8939902
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta antibody
Anti-Pgc-1-Beta antibody
Anti-Ppar-Gamma Coactivator 1-Beta antibody
Anti-Ppargc-1-Beta antibody
Anti-Pgc-1-Related Estrogen Receptor Alpha Coactivator antibody
Anti-PPARGC1B antibody
Anti-PERC antibody
Anti-PGC1 antibody
Anti-PGC1B antibody
Anti-PPARGC1 antibody

Information sourced from Uniprot.org

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