| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PPARGC1B (850-950) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PPARGC1B |
| Gene ID: |
133522 |
| Uniprot ID: |
PRGC2_HUMAN |
| Immunogen Region: |
850-950 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 850-950 of human PGC1 beta (NP_001166170.1). |
| Immunogen Sequence: |
SSRELKRRFEVFGEIEECEV LTRNRRGEKYGFITYRCSEH AALSLTKGAALRKRNEPSFQ LSYGGLRHFCWPRYTDYDSN SEEALPASGKSKYEAMDFDS L |
| Tissue Specificity | Ubiquitous with higher expression in heart, brain and skeletal muscle. |
| Function | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. |
| Protein Name | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-BetaPgc-1-BetaPpar-Gamma Coactivator 1-BetaPpargc-1-BetaPgc-1-Related Estrogen Receptor Alpha Coactivator |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-8939902 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta antibodyAnti-Pgc-1-Beta antibodyAnti-Ppar-Gamma Coactivator 1-Beta antibodyAnti-Ppargc-1-Beta antibodyAnti-Pgc-1-Related Estrogen Receptor Alpha Coactivator antibodyAnti-PPARGC1B antibodyAnti-PERC antibodyAnti-PGC1 antibodyAnti-PGC1B antibodyAnti-PPARGC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
