| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PON2 (1-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PON2 |
| Gene ID: |
5445 |
| Uniprot ID: |
PON2_HUMAN |
| Immunogen Region: |
1-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human PON2 (NP_000296.2). |
| Immunogen Sequence: |
MGRLVAVGLLGIALALLGER LLALRNRLKASREVESVDLP HCHLIKGIEAGSEDIDILPN GLAFFSVGLKFPGLHSFAPD KPGGILMMDLKEEKPRAREL RISRGFDLASFNPHGISTFI DNDDTVYLFVVNHPEFKNTV EIFKFEEAENSLLHLKTVKH ELLPSVNDITAVGPAHFYAT NDHYFSDPFLKYLETYLNLH WANVVYYSPN |
| Tissue Specificity | Widely expressed with highest expression in liver, lung, placenta, testis and heart. |
| Post Translational Modifications | The signal sequence is not cleaved. |
| Function | Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. |
| Protein Name | Serum Paraoxonase/Arylesterase 2Pon 2Aromatic Esterase 2A-Esterase 2Serum Aryldialkylphosphatase 2 |
| Database Links | Reactome: R-HSA-2142688 |
| Cellular Localisation | MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Serum Paraoxonase/Arylesterase 2 antibodyAnti-Pon 2 antibodyAnti-Aromatic Esterase 2 antibodyAnti-A-Esterase 2 antibodyAnti-Serum Aryldialkylphosphatase 2 antibodyAnti-PON2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and PON2 knockout (KO) HeLa cells, using [KO Validated] PON2 Rabbit polyclonal antibody (STJ11100728) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89666/358163/STJ11100728_1__11107.1713122465.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and PON2 knockout (KO) HeLa cells, using [KO Validated] PON2 Rabbit polyclonal antibody (STJ11100728) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")
