| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PNKD |
| Gene ID: | 25953 |
| Uniprot ID: | PNKD_HUMAN |
| Immunogen Region: | 1-270 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PNKD (NP_056303.3). |
| Immunogen Sequence: | MAAVVAATALKGRGARNARV LRGILAGATANKASHNRTRA LQSHSSPEGKEEPEPLSPEL EYIPRKRGKNPMKAVGLAWY SLYTRTWLGYLFYRQQLRRA RNRYPKGHSKTQPRLFNGVK VLPIPVLSDNYSYLIIDTQA QLAVAVDPSDPRAVQASIEK EGVTLVAILCTHKHWDHSGG NRDLSRRHRDCRVYGSPQDG IPYLTHPLCHQDVVSVGRLQ IRALATPGHTQGHLVYLLD |
| Tissue Specificity | Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only. |
| Function | Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. |
| Protein Name | Probable Hydrolase PnkdMyofibrillogenesis Regulator 1Mr-1Paroxysmal Nonkinesiogenic Dyskinesia ProteinTrans-Activated By Hepatitis C Virus Core Protein 2 |
| Database Links | Reactome: R-HSA-9864848 Q8N490-2 |
| Cellular Localisation | Isoform 1: MembranePeripheral Membrane ProteinIsoform 2: CytoplasmNucleusIsoform 3: Mitochondrion |
| Alternative Antibody Names | Anti-Probable Hydrolase Pnkd antibodyAnti-Myofibrillogenesis Regulator 1 antibodyAnti-Mr-1 antibodyAnti-Paroxysmal Nonkinesiogenic Dyskinesia Protein antibodyAnti-Trans-Activated By Hepatitis C Virus Core Protein 2 antibodyAnti-PNKD antibodyAnti-KIAA1184 antibodyAnti-MR1 antibodyAnti-TAHCCP2 antibodyAnti-FKSG19 antibodyAnti-UNQ2491 antibodyAnti-PRO5778 antibody |
Information sourced from Uniprot.org