Western blot analysis of extracts of various cell lines, using PLXNB2 antibody (STJ112109) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PLXNB2 antibody (1080-1200) (STJ112109)

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STJ112109
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PLXNB2
Gene ID: 23654
Uniprot ID: PLXB2_HUMAN
Immunogen Region: 1080-1200
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1080-1200 of human PLXNB2 (NP_036533.2).
Immunogen Sequence: ALLRTEAGAFEYVPDPTFEN FTGGVKKQVNKLIHARGTNL NKAMTLQEAEAFVGAERCTM KTLTETDLYCEPPEVQPPPK RRQKRDTTHNLPEFIVKFGS REWVLGRVEYDTRVSDVPLS L
Function Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling. Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development. Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Also acts as a cell surface receptor for angiogenin (ANG).promoting ANG endocytosis and translocation to the cytoplasm or nucleus. Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development. Regulates the migration of cerebellar granule cells in the developing brain. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. May modulate the activity of RAC1 and CDC42.
Protein Name Plexin-B2
Mm1
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Plexin-B2 antibody
Anti-Mm1 antibody
Anti-PLXNB2 antibody
Anti-KIAA0315 antibody

Information sourced from Uniprot.org

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