| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Plectin (4401-4609) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S3935RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PLEC |
| Gene ID: |
5339 |
| Uniprot ID: |
PLEC_HUMAN |
| Immunogen Region: |
4401-4609 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 4401-4609 of human Plectin (NP_958782.1). |
| Immunogen Sequence: |
RTQLASWSDPTEETGPVAGI LDTETLEKVSITEAMHRNLV DNITGQRLLEAQACTGGIID PSTGERFPVTDAVNKGLVDK IMVDRINLAQKAFCGFEDPR TKTKMSAAQALKKGWLYYEA GQRFLEVQYLTGGLIEPDTP GRVPLDEALQRGTVDARTAQ KLRDVGAYSKYLTCPKTKLK ISYKDALDRSMVEEGTGLRL LEAAAQSTK |
| Tissue Specificity | Widely expressed with highest levels in muscle, heart, placenta and spinal cord. |
| Post Translational Modifications | Phosphorylated by CDK1.regulates dissociation from intermediate filaments during mitosis. |
| Function | Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. |
| Protein Name | PlectinPcnPltnHemidesmosomal Protein 1Hd1Plectin-1 |
| Database Links | Reactome: R-HSA-2022090Reactome: R-HSA-264870Reactome: R-HSA-446107 |
| Cellular Localisation | CytoplasmCytoskeletonCell JunctionHemidesmosome |
| Alternative Antibody Names | Anti-Plectin antibodyAnti-Pcn antibodyAnti-Pltn antibodyAnti-Hemidesmosomal Protein 1 antibodyAnti-Hd1 antibodyAnti-Plectin-1 antibodyAnti-PLEC antibodyAnti-PLEC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
