| Host: |
Mouse |
| Applications: |
IF/IP/WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Plakoglobin is suitable for use in Immunofluorescence, Immunoprecipitation and Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
15F11 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 0.1% BSA and 0.02% sodium azide |
| Concentration: |
100 ug/mL |
| Dilution Range: |
WB 1:10IP 1:10IF 1:10 |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Background | Plakoglobin, also known as gamma-catenin belongs together with alpha-and beta catenin to the catenin family. Catenins mediates cell-cell adhesion by interaction with cadherins. Plakoglobin is found in desmosomes and adherens junctions. Plakoglobin is highly homologous to beta-catenin although its function differs from that of beta-catenin. Whereas beta-catenin has been found in potentiating hyperproliferation and tumor formation, plakoglobin can suppress tumorigenicity. Overexpression of plakoglobin has been shown to suppress cell proliferation and cell tumorigenicity in animals. Furthermore reduced plakoglobin expression has been found in tumor tissues and metastatic lesions of renal cells, esophageal carcinomas and in skin carcinomas. The monoclonal antibody 15F11 cross reacts with rat and weakly with mouse. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
