| Tissue Specificity | Detected in heart, pancreas, brain, kidney, skeletal muscle and lung. |
| Function | Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes such as signal transduction, vesicle trafficking, actin cytoskeleton dynamics, cell adhesion, and cell motility. PtdIns(4,5)P2 can directly act as a second messenger or can be utilized as a precursor to generate other second messengers: inositol 1,4,5-trisphosphate (IP3), diacylglycerol (DAG) or phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3/PIP3). Mediates RAC1-dependent reorganization of actin filaments. Contributes to the activation of phospholipase PLD2. Together with PIP5K1A, is required, after stimulation by G-protein coupled receptors, for the synthesis of IP3 that will induce stable platelet adhesion. |
| Protein Name | Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 BetaPip5k1-BetaPtdins(4p-5-Kinase 1 BetaPhosphatidylinositol 4-Phosphate 5-Kinase Type I BetaPip5kibetaProtein Stm-7Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-201688Reactome: R-HSA-6811558 |
| Cellular Localisation | CytoplasmCytosolCell MembraneEndomembrane SystemAssociated With Membranes |
| Alternative Antibody Names | Anti-Phosphatidylinositol 4-Phosphate 5-Kinase Type-1 Beta antibodyAnti-Pip5k1-Beta antibodyAnti-Ptdins(4p-5-Kinase 1 Beta antibodyAnti-Phosphatidylinositol 4-Phosphate 5-Kinase Type I Beta antibodyAnti-Pip5kibeta antibodyAnti-Protein Stm-7 antibodyAnti-Type I Phosphatidylinositol 4-Phosphate 5-Kinase Beta antibodyAnti-PIP5K1B antibodyAnti-STM7 antibody |
Information sourced from Uniprot.org
