• Immunohistochemistry analysis of paraffin-embedded human brain, using RyR2 (Phospho-Ser2808) Antibody. The picture on the right is blocked with the phospho peptide.

Anti-Phospho-RYR2-Ser2808 antibody (2774-2823 aa) (STJ91127)

SKU:
STJ91127

Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-Ryanodine receptor 2-Ser2808 (2774-2823 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RYR2
Gene ID: 6262
Uniprot ID: RYR2_HUMAN
Immunogen Region: 2774-2823 aa
Specificity: Phospho-RyR-2 (S2808) Polyclonal Antibody detects endogenous levels of RyR-2 protein only when phosphorylated at S2808.
Immunogen: The antiserum was produced against synthesized peptide derived from the human RyR2 around the phosphorylation site of Ser2808 at the amino acid range 2774-2823
Post Translational Modifications Channel activity is modulated by phosphorylation. Phosphorylation at Ser-2808 and Ser-2814 increases the open probability of the calcium channel. Phosphorylation is increased in failing heart, leading to calcium leaks and increased cytoplasmic Ca(2+) levels. Phosphorylation at Ser-2031 by PKA enhances the response to lumenal calcium.
Function Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) cytosolic levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.
Protein Name Ryanodine Receptor 2
Ryr-2
Ryr2
Hryr-2
Cardiac Muscle Ryanodine Receptor
Cardiac Muscle Ryanodine Receptor-Calcium Release Channel
Type 2 Ryanodine Receptor
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-5578775
Cellular Localisation Sarcoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Ryanodine Receptor 2 antibody
Anti-Ryr-2 antibody
Anti-Ryr2 antibody
Anti-Hryr-2 antibody
Anti-Cardiac Muscle Ryanodine Receptor antibody
Anti-Cardiac Muscle Ryanodine Receptor-Calcium Release Channel antibody
Anti-Type 2 Ryanodine Receptor antibody
Anti-RYR2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance