| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phospho-MKNK1-T197/202 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MKNK1 |
| Gene ID: |
8569 |
| Uniprot ID: |
MKNK1_HUMAN |
| Immunogen: |
A synthetic phosphorylated peptide around T197 & T202 of rat MKNK1 (NP_001037732.1). |
| Immunogen Sequence: |
ITTPELTT |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Dual phosphorylation of Thr-250 and Thr-255 activates the kinase. Phosphorylation of Thr-385 activates the kinase. MAPK3/ERK1 is one of the kinases which activate MKNK1/MNK1. Phosphorylation by PAK2 leads to a reduced phosphorylation of EIF4G1. |
| Function | May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. |
| Protein Name | Map Kinase-Interacting Serine/Threonine-Protein Kinase 1Map Kinase Signal-Integrating Kinase 1Mapk Signal-Integrating Kinase 1Mnk1 |
| Database Links | Reactome: R-HSA-1295596 |
| Cellular Localisation | Isoform 2: CytoplasmIsoform 3: CytoplasmNucleus |
| Alternative Antibody Names | Anti-Map Kinase-Interacting Serine/Threonine-Protein Kinase 1 antibodyAnti-Map Kinase Signal-Integrating Kinase 1 antibodyAnti-Mapk Signal-Integrating Kinase 1 antibodyAnti-Mnk1 antibodyAnti-MKNK1 antibodyAnti-MNK1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
