| Post Translational Modifications | Transiently phosphorylated on tyrosine residues by BTK in response to B-cell receptor stimulation. Phosphorylation on Tyr-248 and Tyr-398, and perhaps, on Tyr-503 contributes to BTK-mediated transcriptional activation. Sumoylated. |
| Function | Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation. |
| Protein Name | General Transcription Factor Ii-IGtfii-ITfii-IBruton Tyrosine Kinase-Associated Protein 135Bap-135Btk-Associated Protein 135Srf-Phox1-Interacting ProteinSpinWilliams-Beuren Syndrome Chromosomal Region 6 Protein |
| Cellular Localisation | CytoplasmNucleusColocalizes With Btk In The Cytoplasm |
| Alternative Antibody Names | Anti-General Transcription Factor Ii-I antibodyAnti-Gtfii-I antibodyAnti-Tfii-I antibodyAnti-Bruton Tyrosine Kinase-Associated Protein 135 antibodyAnti-Bap-135 antibodyAnti-Btk-Associated Protein 135 antibodyAnti-Srf-Phox1-Interacting Protein antibodyAnti-Spin antibodyAnti-Williams-Beuren Syndrome Chromosomal Region 6 Protein antibodyAnti-GTF2I antibodyAnti-BAP135 antibodyAnti-WBSCR6 antibody |
Information sourced from Uniprot.org
