|STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
|Rabbit polyclonal antibody anti-Phospho-EEF2K-S366 is suitable for use in Western Blot research applications.
|PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
|Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
|A synthetic phosphorylated peptide around S366 of human EEF2K (NP_037434.1).
| Post Translational Modifications
| Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
| Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
| Protein Name
| Eukaryotic Elongation Factor 2 KinaseEef-2 KinaseEef-2kCalcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase
| Database Links
| Reactome: R-HSA-166208
| Alternative Antibody Names
| Anti-Eukaryotic Elongation Factor 2 Kinase antibodyAnti-Eef-2 Kinase antibodyAnti-Eef-2k antibodyAnti-Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase antibodyAnti-EEF2K antibody
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance