| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Phospho-Epithelial discoidin domain-containing receptor 1-Tyr513 is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:10000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DDR1 |
| Gene ID: | 780 |
| Uniprot ID: | DDR1_HUMAN |
| Specificity: | This detects endogenous levels of DDR1 (Phospho-Tyr513) |
| Immunogen: | Synthesized phospho derived from the human DDR1 (Phospho-Tyr513) |
| Post Translational Modifications | Autophosphorylated in response to fibrillar collagen binding. Glycosylation of Asn-211, but apparently not of Asn-260 or Asn-394, prevents autophosphorylation from occurring in the absence of collagen. |
| Function | Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing. Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11. |
| Protein Name | Epithelial Discoidin Domain-Containing Receptor 1 Epithelial Discoidin Domain Receptor 1 Cd167 Antigen-Like Family Member A Cell Adhesion Kinase Discoidin Receptor Tyrosine Kinase Hgk2 Mammary Carcinoma Kinase 10 Mck-10 Protein-Tyrosine Kinase 3a Protein-Tyrosine Kinase Rtk-6 Trk E Tyrosine Kinase Ddr Tyrosine-Protein Kinase Cak Cd Antigen Cd167a |
| Database Links | Reactome: R-HSA-3000171 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cell Membrane Isoform 3: Secreted Isoform 4: Cell Membrane |
| Alternative Antibody Names | Anti-Epithelial Discoidin Domain-Containing Receptor 1 antibody Anti-Epithelial Discoidin Domain Receptor 1 antibody Anti-Cd167 Antigen-Like Family Member A antibody Anti-Cell Adhesion Kinase antibody Anti-Discoidin Receptor Tyrosine Kinase antibody Anti-Hgk2 antibody Anti-Mammary Carcinoma Kinase 10 antibody Anti-Mck-10 antibody Anti-Protein-Tyrosine Kinase 3a antibody Anti-Protein-Tyrosine Kinase Rtk-6 antibody Anti-Trk E antibody Anti-Tyrosine Kinase Ddr antibody Anti-Tyrosine-Protein Kinase Cak antibody Anti-Cd Antigen Cd167a antibody Anti-DDR1 antibody Anti-CAK antibody Anti-EDDR1 antibody Anti-NEP antibody Anti-NTRK4 antibody Anti-PTK3A antibody Anti-RTK6 antibody Anti-TRKE antibody |
Information sourced from Uniprot.org