| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:2500-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | CAMK2A |
| Gene ID: | 815 |
| Uniprot ID: | KCC2A_HUMAN |
| Immunogen Region: | 300-400 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human Camk2a (NP_741960.1). |
| Immunogen Sequence: | KGAILTTMLATRNFSGGKSG GNKKSDGVKESSESTNTTIE DEDTKVRKQEIIKVTEQLIE AISNGDFESYTKMCDPGMTA FEPEALGNLVEGLDFHRFYF E |
| Post Translational Modifications | Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7. |
| Function | Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity. |
| Protein Name | Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha Cam Kinase Ii Subunit Alpha Camk-Ii Subunit Alpha |
| Database Links | Reactome: R-HSA-111932 Reactome: R-HSA-3371571 Reactome: R-HSA-399719 Reactome: R-HSA-4086398 Reactome: R-HSA-438066 Reactome: R-HSA-442982 Reactome: R-HSA-5576892 Reactome: R-HSA-5578775 Reactome: R-HSA-5673000 Reactome: R-HSA-5673001 Reactome: R-HSA-6802946 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-877300 Reactome: R-HSA-9022692 Reactome: R-HSA-936837 Reactome: R-HSA-9609736 Reactome: R-HSA-9617324 Reactome: R-HSA-9620244 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
| Cellular Localisation | Synapse Postsynaptic Density Cell Projection Dendritic Spine Dendrite Postsynaptic Lipid Rafts |
| Alternative Antibody Names | Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha antibody Anti-Cam Kinase Ii Subunit Alpha antibody Anti-Camk-Ii Subunit Alpha antibody Anti-CAMK2A antibody Anti-CAMKA antibody Anti-KIAA0968 antibody |
Information sourced from Uniprot.org