| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PHLDA3 (1-127) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PHLDA3 |
| Gene ID: |
23612 |
| Uniprot ID: |
PHLA3_HUMAN |
| Immunogen Region: |
1-127 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-127 of human PHLDA3 (NP_036528.1). |
| Immunogen Sequence: |
MTAAATATVLKEGVLEKRSG GLLQLWKRKRCVLTERGLQL FEAKGTGGRPKELSFARIKA VECVESTGRHIYFTLVTEGG GEIDFRCPLEDPGWNAQITL GLVKFKNQQAIQTVRARQSL GTGTLVS |
| Tissue Specificity | Widely expressed with lowest expression in liver and spleen. |
| Function | p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. |
| Protein Name | Pleckstrin Homology-Like Domain Family A Member 3Tdag51/Ipl Homolog 1 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Pleckstrin Homology-Like Domain Family A Member 3 antibodyAnti-Tdag51/Ipl Homolog 1 antibodyAnti-PHLDA3 antibodyAnti-TIH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
